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KMID : 1059520120560020251
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Journal of the Korean Chemical Society
2012 Volume.56 No. 2 p.251 ~ p.256
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Synthesis and Antidiabetic Evaluation of Benzothiazole Derivatives
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Mariappan G.
Prabhat P.
Sutharson L.
Banerjee J.
Patangia U.
Nath S.
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Abstract
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A novel series of benzothiazole derivatives were synthesized and assayed in vivo to investigate their hypoglycemic activity by streptozotocin-induced diebetic model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well known antidiabetic agent as a reference drug. All the compounds were effective, amongst them 3d showed more prominent activity at 100 mg/kg p.o. The experimental results are statistically significant at p<0.01 and p<0.05 level.
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KEYWORD
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Benzothiazole, Hypoglycemic activity, Riluzole, Antitumor activity, Diabetes
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